Radamel Falcao, controversially left out of that match, could come back in up front as a result and Ander Herrera could also be given a rare league start.
Ashley Young is United's only other absentee but Marcos Rojo and Rafael are both in contention after recovering from their injuries.
These two sides last met back in September at Old Trafford and the Reds emerged comfortable 4-0 winners in LVG's first victory as boss.
Despite their lowly league position- only Leicester are below Harry Redknapp's strugglers- the trip to West London will pose a test for Louis van Gaal's side.
Only Hull and Liverpool have come away from Loftus Road with all three points, all five of their Premier League wins have come at home and in 13-goal Charlie Austin, Rangers possess a natural finisher of genuine quality.
United's form on the road is patchy to say the least with our only away wins coming at Arsenal and Southampton in the league plus the FA Cup win at Yeovil.
Speaking at his post match press conference on Friday, van Gaal doesn't expect an easy game.
He said: "It's always the same, no game is a guarantee, Manchester United are a big club and we are aware that our opponents QPR have been strong on their home ground.
"They have a style of play that is very difficult for us, we have seen that already. They play a lot of long balls, they have strong strikers and we have to find a plan to beat them because of this.
"Going forward, the Champions League is our goal, of course we want to be champions but you have to win matches at Southampton or Aston Villa.
"When you do not do this you cannot be champions but our goal is now to be within the first four because we want to play Champions League."
Match odds: QPR 4/1 United 3/5 Draw 31/10 (bwin)
Form guide: QPR W L D D L L United: D W D D W L
Referee: N Swarbrick
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