Manchester United and Cambridge United will contest a fourth-round replay at Old Trafford on Tuesday 3 February (KO 19:45 GMT) and go into Monday's FA Cup fifth-round draw as the highest and lowest ranked teams still left in the draw.
The two sides, who drew 0-0 on Friday night at the Abbey Stadium, will find out which team awaits the replay's winners when the draw is made at around 1920 GMT this evening.
United and Cambridge will be represented by ball number two.
All three teams above the Reds in the Barclays Premier League- Chelsea, Manchester City and Southampton- were knocked out of the FA Cup on Saturday, all on home turf.
The biggest shock, Bradford City's 4-2 comeback win at Stamford Bridge, featured former United trainee Ben Williams playing in goal for the victorious League One side.
The top flight sides in action saved some face for the Premier League on Sunday when Arsenal, Aston Villa and West Ham United all beat lower-league teams to join West Brom, Crystal Palace and Leicester City in the last 16.
Also through are Championship sides Blackburn Rovers, Derby County, Middlesbrough and Reading but several ties will, like Cambridge vs United, be settled by a replay.
Preston vs Sheffield United, Sunderland vs Fulham and Liverpool vs Bolton all went to replays while Rochdale and Stoke City will meet for the first time at Spotland tonight, after the draw.