United head to Selhurst Park off the back of three successive draws in all competitions looking to rediscover the poise and fire that brushed Everton aside in our last league away outing.
Alan Pardew's side started the season well- winning four of their first seven in the league- but they have lost their last three and come into this one off the back of a 5-1 reverse at City in the Cup in midweek.
Antonio Valencia is unavailable due to the foot injury he sustained in the derby, James Wilson and Memphis Depay both picked up knocks against Middlesbrough and the Reds will also again be without long term absentees Paddy McNair and Luke Shaw.
For Palace, £10m club record signing and midfield playmaker Yohan Cabaye is a doubt which will be a huge blow to the Eagles hopes of a famous victory over United.
Despite the potential loss of their star man, this Palace side is packed with pace and trickery, with the Eagles in-form winger Yannick Bolasie and former United man Wilfried Zaha tasked with doing the damage against the Reds.
"Memphis and Wilson are injured and we shall have to wait and see how bad it is, but they shall not be available for the selection against Crystal Palace" said United boss Louis van Gaal, who paid tribute to the club's "unbelievable" fans.
"I shall do everything for this club because these fans are unbelievable and of course like me and everyone here they want to win so we shall do this and we shall continue."
"Crystal Palace is a difficult opponent I believe as they have good players who can hurt us, they are quick and skilful and attack well so we shall need to play well both in the defensive phase and the offensive phase" added the boss.
United won both matches against the Eagles last term, both by a single goal with Juan Mata scoring the winner at Old Trafford before the Spaniard netted a penalty in the 2-1 win at Selhurst Park in May with Marouane Fellaini nicking the winner for United.
Form guide: Palace W W W L L L United W L W D D D
Match odds: Palace 14/5 Draw 5/2 United 11/10
Referee: Mike Jones (Chester)