The massive matches continue to come thick and fast for United as the Reds prepare to fly out to Moscow ahead of Wednesday's testing Group B encounter with CSKA on Champions League Matchday Three.
We have met CSKA twice before- in the group stage in 2009- winning 1-0 away and mouting a late comeback to draw 3-3 at home.
We go into this one off the back of a vital win over Wolfsburg last time out to leave all four clubs in this section on three points so victory on Wednesday will go a long way to deciding who takes pole position in the battle to qualify for the knockout stages.
Antonio Valencia and Sergio Romero will both come back into the squad having missed the trip to Everton, but James Wilson is ill so will not travel and Paddy McNair, Luke Shaw and Ashley Young also all miss out.
There are no fresh injury concerns for the Reds (United boss Louis van Gaal will speak to the media at around 1900 BST this evening).
United midfielder Marouane Fellaini admitted United have one eye on Sunday's derby with City, but insisted that the team are fully focused on Wednesday's clash in the Russian capital.
Speaking to MUTV, the Belgian said:
"Of course we know that Sunday's match against Manchester City is one of the biggest and we cannot forget that, but now we are focused on the match in Moscow and we know it will be very different from in England
"It is a very important match for everyone and we know how we need to play as the manager has showed us videos on the opponents.
"Both teams want to win so it will be different to domestic football, but we are looking forward to this game and as I said before, it is very important."
United fans will be familiar with CSKA winger Zoran Tosic (the Serbian had a brief spell at Old Trafford in 2009), whilst Seydou Doumbia is the hosts top scorer this season.
Wolfsburg host PSV in the other Group B fixture on Wednesday.
Form guide: CSKA D D W W L W United W W W W L W
Match odds: CSKA 15/8 Draw 21/10 United 8/5 (William Hill)
Referee: Carlos Carballo (Spain)
United travelling squad: De Gea, Romero, Johnstone, Darmian, Smalling, Jones, Rojo, Blind, Carrick, Schweinsteiger, Schneiderlin, Fellaini, Valencia, Pereira, Mata, Herrera, Memphis, Lingard, Rooney, Martial.