United make the traditionally tricky trip to the blue half of Merseyside to face an Everton side in equally indifferent form.
In the first of three games in a week, the trip to Goodison Park is swiftly followed by the conclusion of our Europa League group campaign and then the visit of Spurs next Sunday.
Wayne Rooney is suspended against his old club after he picked up his fifth booking of the season against West Ham.
Luke Shaw could miss out with Eric Bailly and Chris Smalling also injured, but Paul Pogba and Marouane Fellaini, against his former side, are available again after serving one-match bans in midweek.
Anthony Martial and Henrikh Mkhitaryan impressed in the West Ham and look to feature with Bastian Schweinsteiger also pushing for inclusion.
The Dutchman made the switch to Goodison Park from Southampton in the summer and, like Jose, saw his new side start well with a seven-match unbeaten run but, like United, they have had something of an inconsistent season.
Bournemouth ended that sequence in September and since then the Toffees have picked up only six points from a possible 21 (including a 5-0 loss to league leaders Chelsea).
Going into this one, they sit a point and a place below us in the table and would leapfrog us with victory.
"Wayne's absence comes in the same sequence of yellow cards that stopped Zlatan playing against Arsenal, and the sequence that stopped Marouane Fellaini and Paul Pogba playing against West Ham - but people make mistakes so it is no problem.
"It is always difficult to go to Everton with a great crowd and a beautiful stadium which is historic for my country so I always enjoy going there.
"I managed against Martinez's Everton, Moyes' Everton and it is always a tricky match, so with the way United are playing and the way Foeman's teams always try to play, it should be a very interesting match.
"I have had many good games at Everton so I am expecting another one on Sunday.
"Koeman has played with three at the back and that is something we work on in training - playing against three defenders and two wing-backs, we have to find the right way to exploit that system as it is one that has good qualities but can create problems. "
Form guide: Everton D L W L D L United L W D W D W
Match odds: Everton 13/5 Draw 12/5 United 11/10
Referee: Michael Oliver