United will move into the top four and set a new club record of 25 league games unbeaten with victory over struggling Swansea.
The 0-0 draw at City on Thursday equalled the previous record set by Sir Alex's title winners in 2010-11 but a win would surpass that mark on Sunday.
Since the 4-0 defeat at Chelsea in October, only Antonio Conte's side and Marco Silva's Hull have beaten us - and both of those came in cup matches.
Swansea should not be taken for granted however, having won on two of their last four visits to Old Trafford.
Their initial 'new manager bounce' under Paul Clement has receded and they currently occupy third from bottom in the table, two points from safety.
Their survival hopes were given a major boost last time out though as a 2-0 win over Stoke City arrested a run of six games without a win.
United are still without long term absentees Phil Jones, Chris Smalling, Marcos Rojo and Zlatan Ibrahimovic.
Juan Mata is nearing a sooner-than-expected return but the game comes too soon for Paul Pogba, who is expected to feature against Celta Vigo on Thursday.
There will be two more players missing against Swansea as Marouane Fellaini begins a three-match ban for his sending off in the derby.
Tim Fosu - Mensah will also miss out having picked up a "significant" shoulder injury as a substitute late on at the Etihad.
Jack Cork (ankle) and Martin Olsson (hamstring) are both doubtful for the visitors.
United manager Jose Mourinho said: "I have seen a big change in the group since I came in.
"There is more togetherness and they were missing the quality that gives you resilience and fight.
"They are ready to go for big things next year, but the reality for now is that we are fighting for the top four and fighting to win the Europa League, so let's go.
"We know that Swansea will be difficult for us, it's never easy to play a struggling team so we have to have the right attitude and mentality and then we can be ready."
Swansea have enjoyed recent success against the Reds and picked up the tag as our "bogey" side after three consecutive 2-1 wins that stretched across two seasons - including an unprecedented league double in 2014-15.
United have redressed that balance against the south Wales side, though, and have emerged the victors in our last two meetings.
Form guide: United W D W W W D Swansea City L D L L L W
Match odds: United 7/2 Draw 4/1 Swansea City 9/1
Referee: Neil Swarbrick (Lancashire)