The manager publicly blasted the 21-year-old's "attitude, focus and commitment" and confirmed that Shaw is fifth choice left-back - a "long way" behind Daley Blind, Marcos Rojo, Matteo Darmian and Ashley Young.
Rojo and Darmian have often been a liability when picked at left-back, Young is a winger by trade and Blind has also hopped on the left-back merry go round.
All are inferior in talent to Shaw, but compensate for that through effort and application.
Despite still appearing to be part of Gareth Southgate's England plans, he's been under-performing in training and hasn't convinced Mourinho.
LVG publicly rebuked Shaw's fitness levels two-and-a-half years ago (even placing him on a weight loss training regime) and it remains an ongoing concern.
Shaw has made only two appearances in four months and didn't even make the bench against West Brom, despite United's injury problems and being fit and available to play.
Academy prospects Axel Tuanzebe and Matty Willock were named as substitutes instead in the clearest indication yet that Shaw looks set to leave.
A damning verdict for a player who looked to have such a bright future at the club when he was signed from Southampton in 2014.
He made the move to United as the world's most expensive teenager and enjoyed a superb start to life at Old Trafford.
Having broken his leg in two places during a Champions League tie in Eindhoven, Shaw was out for almost a year and, since then, his form and fitness has plummeted.
Until that debilitating injury, Shaw was United's outstanding player of the campaign and was flourishing in tandem with Memphis Depay down the left.
Mourinho has also criticised Shaw after the 3-1 defeat at Watford in September, and for "refusing to play" in the November match at Swansea.
Jose is also believed to tried an "arm round the shoulder" approach with the player and this latest outburst could represent Shaw's last chance to prove his manager wrong.
Unless he does so, then the left-back looks certain to be the first casualty of Jose's tenure, a sad end for a player who was tipped to become a star and shine at United for many years to come.