United signed off their US Tour with defeat to French champions PSG in Chicago but this was a game that LVG and his side will take plenty of positives from.
The Reds came into the match with three wins from three on Tour, but indecision at the back was United's undoing and, despite creating numerous chances, we slipped to defeat through an won goal from Luke Shaw and Zlatan Ibrahimovic's 34th-minute strike.
One of the plus points from the game was the continued development of the partnership between Memphis and Wayne Rooney, and the pair looked lively early on.
In the 17th minute, Depay was presented with a golden chance to put the Reds ahead when a lovely ball from Bastian Schweinsteiger found Rooney, who slipped in Memphis, but he could only blast the effort wide.
PSG went close soon afterwards when Ibrahimovic headed a Lucas Moura corner narrowly wide, while the Reds did put the ball in on 22 minutes through Juan Mata, but he was flagged offside.
Against the run of play, PSG took the lead three minutes later after confusion in the United back-line.
A long ball forward was chased down by Blaise Matudi and, as Phil Jones and Shaw chased back, De Gea raced from his goal and was left stranded when SHaw's inadvertent touch rolled past him and into the net.
Rooney went close twice in quick succession when he flashed a couple of efforts narrowly over the bar before PSG doubled their advantage through Ibrahimovic, who picked up the ball in midfield, played a one-two with Maxwell before slotting home unmarked for close range.
Memphis had a free-kick well saved by Kevin Trapp shortly before the interval but the Reds went in at the break two down with a tough job in the second half to preserve our 100% record on the Tour.
Sam Johnstone, Andreas Pereira and Morgan Schneiderlin were all introduced at the break, and the Brazilian played in Rooney- who in turn picked out Depay- but the Dutchman's effort lacked power and failed to trouble Trapp.
PSG held firm at the back thereafter, with the Reds unable to mount a fightback, and LVG's men now return to Manchester to continue preparations for the start of the new campaign, with all the focus now on ensuring a winning start to the competitive season.