The Premier League may be taking a two week sabbatical to make way for internationals but there's no rest for the wicked as several United stars jet off to join up with their countries.
Daley Blind and Memphis are included in the Netherlands squad to face Euro 2016 hosts France in an Amsterdam friendly, with Anthony Martial likely to spearhead the attack for Les Bleus and Morgan Schneiderlin also set to be involved.
The Netherlands then travel to Wembley to face England on 29 March, but Roy Hodgson's side will be without skipper Wayne Rooney through injury.
Chris Smalling is the only United player in the hosts' squad but Jesse Lingard has been touted as a possible replacement for the injured Raheem Sterling.
Bastian Schweinsteiger and World champions Germany provide the subsequent opposition the preceding Saturday before Joachim Low's outfit take on Matteo Darmian's Italy in Rome in another friendly fixture.
Darmian is in the Azzuri's squad for their schedule, which also includes a clash with Spain this coming Thursday.
David de Gea and Juan Mata are both in the European champions squad with a friendly trip to Romania also on the horizon.
Paddy McNair is set to represent Northern Ireland against Wales on Thursday and Slovenia next Monday while Marouane Fellaini looks set to feature for Belgium against Cristiano Ronaldo's Portugal on the 29th March.
Guillermo Varela has been handed a first senior Uruguayan call-up for the World Cup qualifiers against Brazil and Peru.
Sergio Romero and Marcos Rojo are in Argentina's plans for their encounters with Chile and Bolivia.
A fourth red in South American action is Antonio Valencia with the fit-again Ecuadorian returning to his country's squad for the fixtures vs Paraguay and Colombia.
Thursday 24 March
Italy v Spain (Darmian, De Gea, Mata)
Wales v Northern Ireland (McNair)
Chile v Argentina (Romero, Rojo)
Ecuador v Paraguay (Valencia)
Friday 25 March
Netherlands v France (Blind, Memphis, Martial, Schneiderlin)
Brazil v Uruguay (Varela)
Saturday 26 March
Germany v England (Schweinsteiger, Smalling)
Sunday 27 March
Romania v Spain (De Gea, Mata)
Monday 28 March
Northern Ireland v Slovenia (McNair)
Tuesday 29 March
Belgium v Portugal (Fellaini)
Germany v Italy (Schweinsteiger, Darmian)
England v Netherlands (Smalling, Blind, Memphis)
France v Russia (Martial, Schneiderlin)
Argentina v Bolivia (Rojo, Romero)
Colombia v Ecuador (Valencia)
Uruguay v Peru (Varela)