Paul Pogba joined that list after limping off early on Thursday and is doubtful with Chris Smalling, Eric Bailly and Antonio Valencia all ruled out and Ander Herrera suspended following his sending off against Burnley.
The struggling Swans sacked manager Francesco Guidolin after a poor start to their season and his replacement Bob Bradley has picked up one point from a possible nine to leave them second bottom of the table (they've not won since the opening weekend).
United are not in action again until the 19th November because of the international break and, with our season yet to get going, a fifth league win of the campaign would prove the perfect tonic for Jose and the team.
On paper, this fixture looks an ideal one in which to return to winning ways but the Swans hold something of a hoodoo over the Reds having won four of the last six matches between the sides.
Wayne Rooney's instinctive winner at Old Trafford in January ended a run of three consecutive defeats against the south Wales side but we've not won at the Liberty since 2013.
Rui Faria will be on the touchline for the Reds as Jose serves his one match ban and the boss has called for a reaction from his side following the defeat in Turkey.
He said: "Football is from the first second and when you give the opponent an early head start it is a completely different game.
"I know that in this moment we are fragile when we go behind in a game and we are not scoring enough goals.
"We have to be strong mentally and we need to be starting games better, and differently, from how we did against Fenerbahce and Chelsea.
"Football is an emotional game and we have to control that emotion on Sunday because we need a good reaction, a strong response, as Swansea are not an easy opponent.
"They are struggling a bit at the moment but every match is difficult so we need to play well."
Despite our injuries, the resultant lack of numbers in midfield and Bastian Schweinsteiger's return to training, Jose has ruled out an inclusion back into the squad for the German World Cup winner.
The boss added: "It is too early for him, he has been with the teams for three or four days but he's not ready to play football at that level yet so he will not play."
Form guide: Swansea L L L L D L United D W L W D L
Match odds: Swansea 4/1 Draw 11/4 United 8/11
Referee: Neil Swarbrick