Fresh from their progress to the Europa League final, United are back in north London for a last ever visit to White Hart Lane.
Spurs will play at Wembley next season while their new £700 million ground is being redeveloped.
Just as we did at Upton Park, United will have the honour of being the home side's last ever opponents before their move to the new stadium for the 2018 - 19 season.
Mauricio Pochettino's side hold a seven point lead over third-place Liverpool and boast one of the strongest home records in the country - with a club record run of 13 successive league wins at the Lane.
Should they avoid defeat against United, it would create another slice of history as their first ever unbeaten home league season.
That has seen them mount another title challenge as Chelsea's closest challengers, but those hopes were extinguished with a surprise 1-0 loss at West Ham last time out.
Chelsea sealed the deal on Friday but Spurs can take solace by the fact that they will finish above fierce local rivals Arsenal for the first time in 21 years following their recent derby win.
Attentions have turned to the European final on May 24 and Jose again looks likely to rotate the team with several key men rested.
Zlatan, Marcos Rojo, Tim Fosu - Mensah, Ashley Young and Luke Shaw are all out for the rest of the season, but Eric Bailly could feature.
The Ivorian will be available for United's three remaining league games after his sending off against Celta and Marouane Fellaini will serve the final game of his three-match domestic suspension.
Axel Tuanzebe is again an option and Juan Mata could also return having remained on the bench in Europe.
Spurs remain without long-term absentees Harry Winks and Erik Lamela but Danny Rose could return after four months out with knee ligament damage.
On his side's league run-in, Jose said: "I approach these games the same, I have to give some players minutes as there are only 15 players.
"In the league we can only finish fifth and sixth, I don't think we can finish fourth and we can win a trophy so that is what we are focusing on.
"We want to give a difficult match for our opponents, we are going to try and play to win but there is one match that is more important than these others.
"But we are not going to say that the match on Sunday is not important."
Form guide: Tottenham W W L W W L United W D D W L D
Match odds: Tottenham 1/4 Draw 7/10 United 14/5
Referee: Jon Moss (County Durham)