United make the short trip to west Yorkshire to face newly promoted Huddersfield with the chance to create history.
If the team can shut out David Wagner's Terriers, it will be United's eighth clean sheet in the first nine league fixtures - a feat no other side has ever achieved in the top flight.
Having all but sealed qualification to the knockout stages of the Champions League in midweek, United return to domestic duty in the third of four successive away games.
The Reds make the 27-mile trip across the Pennines for our first ever visit to the John Smith's Stadium - our first competitive meeting with Huddersfield for 45 years.
Marcus Rashford limped off with a knee injury against Benfica but has been passed fit and is available for selection.
Michael Carrick, Paul Pogba, Eric Bailly, Phil Jones and Marouane Fellaini are all sidelined so Jose looks set to name an unchanged side from the 1-0 win in Portugal.
Striker Steve Mounie is expected to feature for Huddersfield, but Philip Billing (ankle) and Collin Quaner (calf) are both ruled out.
The Terriers began their first ever Premier League campaign in fine form with a 3-0 thumping of Palace, which they followed up with a 1-0 win over Newcastle.
Life at the top level has been harder for them since then, though, having failed to win any of their last six league games.
They go into this match on the back of two successive defeats to Tottenham and Swansea and sit twelfth in the table.
Despite the hosts indifferent form, Jose said that neither he nor the team will underestimate Wagner's men.
He said: "The place will be buzzing, the people will be happy to have a big club, a famous club, in their city, and it will be a big motivation for them.
"We know that but I think we are going to be ready.
"Everybody knows the Premier League and what it means for the new teams, every team in the Premier League is good, every team in the league thinks and believes that they can win against every opponent.
It is another match away from home and nobody else is coming back.
"We have the same players we had for the Benfica match."
Form guide: Huddersfield Town L D L D L L United W W W W D W
Match odds: Huddersfield Town 33/1 Draw 4/1 United 11/2
Referee: Lee Mason (Lancashire)