United have an early opportunity to bounce back from Saturday's loss as we continue our Carabao Cup defence in south Wales.
Less than 48 hours after the shock defeat at the John Smith's Stadium comes a chance for the Reds to offer a much-needed response, ahead of Spurs visit to Old Trafford on Saturday.
United midfield Juan Mata said: "It's time to learn from mistakes and keep going, as we always do, we need to show that the team sticks together when things don't go so well.
"Since the European Super Cup defeat, we've been performing well against all opponents, but on Saturday Huddersfield took all three points and we congratulate them.
"We move on, this is not a sprint but a marathon and there's still a long way to go."
The Reds travel to Paul Clement's Swansea in the fourth round boosted by the return of Ivorian centre-back Eric Bailly.
Phil Jones will be assessed having limped off in that loss to Huddersfield, with Marcos Rojo, Marouane Fellaini, Michael Carrick, Paul Pogba and Zlatan Ibrahimovic all ruled out.
Sergio Romero, Daley Blind, Luke Shaw and Matteo Darmian are all in contention to feature for a rotated Reds side.
For the hosts, Kyle Bartley (knee), Renato Sanches (thigh) and Wilfried Bony (thigh) are all sidelined, and Leroy Fer is suspended.
The Swans come into the game in indifferent form, having picked up four points from their last six league games after a 2-1 defeat to Leicester, with Michael Appleton in caretaker charge of the Foxes.
Both the Swans and United saw off lower league opposition in the third round to set up this first ever League Cup meeting.
Goals from Alfie Mawson and Jordan Ayew earned Clement's side a 2-0 win at Championship Reading while United also saw off second tier opposition last time out.
Nigel Clough's Burton Albion were put to the sword at Old Trafford as the holders brushed aside the Brewers with an Anthony-Martial inspired 4-1 thrashing.
In the pick of the other fourth round ties, Arsenal and Manchester City both face Championship opposition, in the shape of Norwich and Wolves respectively.
On Wednesday, Chelsea host managerless Everton and West Ham travel to Spurs in a London derby between two sides in starkly contrasting form.
Form guide: Swansea City D W L L W L United W W W D W L
Match odds: Swansea City 13/2 Draw 16/5 United 4/1
Referee: Bobby Madley (West Yorkshire)