Having won six of our first seven league games, October looks set to be United's most demanding month of the season so far.
The team will play six matches in three different competitions in the space of 17 days and will go a long way to determine whether the Reds can last the course, both domestically and in Europe.
The Premier League makes way for the latest round of international fixtures (yawn) but returns with a bang in a fortnight's time.
Jose's unbeaten Reds travel to Anfield for the most eagerly anticipated fixture on the calendar and one that looks to be United's most difficult challenge of the season so far.
The Reds of Manchester and Merseyside meet competitively for the 199th time on Saturday 14th October with a traditional lunch-time kick off.
Like United, Jurgen Klopp's side are blessed with a wonderful array of attacking talent, underlined by their continued inability to defend.
That's followed four days later by our trip to Portugal to face a below-par Benfica on Champions League Matchday Three.
Rui Vitoria's side have lost both of their encounters in the competition thus far, but they are the top seeds in the group and the trip to Lisbon is never one to be taken lightly.
It's rare these days - particularly in the Premier League - to visit a ground that you've never played at before, but that's what awaits Jose and United on the 21st.
We travel across the Pennines to the John Smith's Stadium to take on David Wagner's newly promoted Huddersfield - the league's surprise package so far - in another rare Saturday 3pm kick off.
The fixtures continue to come thick and fast with United in action again three days later, this time in the Carabao Cup.
It's likely to be a rotated Reds team in south Wales in our latest defence of that competition at Swansea City in the fourth round.
The final league game of the month sees another of the Premier League's high flyers visit Old Trafford in the shape of Mauricio Pochettino's Tottenham on the 28th (another 12.30 kick off).
Spurs - having finished second in each of the last two seasons - have struggled to adapt to their Wembley surroundings but boast a 100% record on the road.
United will look to avoid a fright on Halloween as Benfica provide the final opposition of the month, and a win could seal qualification the Champions League knockouts with two games to spare.