Romelu Lukaku vs Giorgio Chiellini/Leonardo Bonucci
With Lukaku struggling for form, his task on Tuesday could hardly be any more difficult in the individual battle with two of the best centre-backs of their generation. Italians Chiellini and Bonucci have been defensive figureheads for both club and country for the best part of the last decade and, although the latter spent last season on loan at Milan, he has played in both of Juve's recent European near misses.
It could well be an old fashioned battle and Lukaku will have to win balls in the air, as well as hold up possession to bring teammates into play. If the ball keeps bouncing off him when he receives it United will have little in the way of a central output.
Anthony Martial vs Joao Cancelo
Cristiano Ronaldo vs David de Gea
Perhaps the most intriguing duel of all, this pits two of the world's best against each other on Ronnie's second return to Old Trafford as an opponent.
After an initially slow start to his Juventus career, Ronaldo has now scored five goals in his last six Serie A appearances and will be hoping that his on-field display will take some of the spotlight off the ongoing rape allegation against him that he strongly denies. With United's leaky and creaking defence, chances to score won't be in short supply for a player who honed his craft at United for six wonderful seasons. Go easy on us, CR7.
Douglas Costa vs Luke Shaw
Costa - in tandem with Paulo Dybala on the opposite flank - will provide pace, guile and firepower behind Ronaldo in Juve's attack. It’s not easy to predict how Massimiliano Allegri will assemble his frontline. Dybala, who played upfront against Young Boys and bagged a hat-trick is just back from a minor injury. The Argentine is accustomed to his role as a number ten, just behind the striker but can be destructive on the right wing too. Luke Shaw has been one of the most consistent players for United this season and will be unfazed by the attacking threats. Should Juan Cuadrado start instead, Shaw might have to deal with tons of crosses targeted at Ronaldo.
Costa on the other hand prefers to cut in and the United left-back’s approach to this will be different. In both cases, Shaw needs to win his battle if United are to take something from the game. The individual head-to-head between their wide men and our full-backs will go a long way to determining the outcome.