This is a dead rubber for the Reds who are safe in fourth, but Hull have to win and hope that Newcastle do not in their game with West Ham in the battle to avoid the final relegation place.
United manager Louis van Gaal has hinted that he will play his strongest available starting XI and that there will be no sentiment from the Dutchman against the Tigers, who of course are manager by former Red hero Steve Bruce.
Addressing the media in his final press conference of the season on Friday, Van Gaal said:
"It shall be the same approach as ever, we need to defend our image as Manchester United and we are ending in fourth position, so we have to give our utmost best.
"We haven't won so many matches away so it's very difficult to beat English Premier League clubs away, particularly when the opponent cannot lose the game.
"We shall do our utmost best- we have to do it for the honesty of the league."
Wayne Rooney is fit to start but a decision on the fitness of David de Gea is yet to be made, with Victor Valdes poised to deputise should the Spaniard fail to recover.
There are no new injury concerns for the Reds.
It would be sad to see Brucey and his side drop into the Championship, and a small part of me hopes they win here to stay up (is that really bad) and relegate Newcastle (which is never a bad thing), but speaking post-match on Friday in his final press conference of the season, LVG said his side would "do what is expected of them."
"I have to play my strongest team, because we have to give everything for the Premier League, our fans, and of course Newcastle United.
"We have taken six points off Newcastle and we have to take six points off Hull City, I think.
"I have said to the players that, in spite of Steve Bruce being a Manchester United guy, we have to ignore that and do what everybody is expecting from us."
Form guide: Hull L W W L L L United W L L L W D
Match odds: Hull 12/5 Draw 11/4 United 5/4
Referee: Lee Probert