Manager Louis van Gaal has his sights set on a 12th FA Cup win for United as his side secured a place in the last 16 on Tuesday.
The Reds are two wins from Wembley after a 3-0 win over Cambridge, and with Chelsea and City both knocked out, are the highest ranked side left in the competition as LVG chases a trophy in his first season in the Old Trafford dugout.
van Gaal's side will face a Preston side who are fourth in League One on the 16th February, a match for which United will be strong favourites to seal a place in the quarter finals.
Speaking after Tuesday's replay win, van Gaal said:
"Cambridge have played very well, a very organised team and with the mentality that was superb, the fans from Cambridge United were fantastic and I congratulate them.
"We did what we had to.
"Every club wants to win the FA Cup, we also. We have to beat Preston and that will not be easy, they won away against a big cup fighter like Sheffield United, so it will be difficult for us to win in Preston North End.
"For the club, the fans and the coach and my staff, we want a title this year.
"The biggest chance of this is in the FA Cup but we still have to win four games to do that.
"We will hope to continue at Preston as it has been a long time since this club has won the FA Cup and this is something that is important to everyone in Manchester United."
The Reds have not won the world's oldest and most famous knockout competition for 11 years, a recent record that United are desperate to put a stop to this season.
Of the current squad, only Robin van Persie and Juan Mata have won the trophy, with Arsenal in 2005 and Chelsea in 2011 respectively.
The Gunners remain slight favourites to retain the trophy they won last season at 5/2, with United second favourites at 13/5 and Liverpool dark horses at 11/2.
United's fifth round match at Preston North End will be televised live on BBC One on Monday 16th February.